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. Author manuscript; available in PMC: 2012 Oct 23.

Published in final edited form as: Nucl Med Biol. 2012 Jun 22;39(7):1012–1018. doi: 10.1016/j.nucmedbio.2012.05.006

Table 1.

Overview of synthesis methods and results for [¹⁸F]EF5 as reported in the literature and from the present work.

	Precursor in mg (μmol)	TFA (ml)	Carrier F₂ (μmol)	TFA removal prior to HPLC purification	MBq [¹⁸F]EF5 at EOS (mCi)	Radiochemical yield (%)	Specific activity (MBq/μmol)
Dolbier et al. [25]	25 (100)	5	66.7	Neutralization/liquid-liquid extraction/evaporation	NA	>10	NA
Kachur et al. [32]	6–8 (24–32)	8	60–70	Evaporation	NA	NA	NA
Eskola et al. [31]	1–1.2 (4–4.5)	0.6–0.7	0.3–1.2	Evaporation	406–1027 (10.9–27.7)	2.8±0.6^a (n=19)	6600±1900
Apte et al. (abstract) [39]	22 (88)	7	NA	Evaporation	444–518 (12–14)	4.7^b (n=8)	67–122
Current work	10 (40)	3	65–90	Neutralization/online-SPE	755–1465 (20.4–39.6)	11±2^a (n=18)	327±95

NA: Not Available.

^a

EOB.

^b

EOS.