Table 2.
Effects of different doses of methylsulfonylmethane (MSM) on the activities of antioxidant enzymes in rats with monocrotaline-(MCT-) induced pulmonary hypertension.
| Control | MCT-induced pulmonary hypertension groups, MSM (mg/kg/day) | ||||||
|---|---|---|---|---|---|---|---|
| 0 | 100 | 200 | 400 | r 2 | P | ||
| CAT (U/mL) | 6.10 ± 0.83 | 2.02 ± 0.33* | 4.16 ± 0.57 | 5.02 ± 0.75 | 7.98 ± 1.68 | 0.48 | <0.001 |
| SOD (U/mL) | 203.33 ± 3.80 | 168.33 ± 6.67** | 206.67 ± 5.11 | 210.00 ± 7.30 | 220.83 ± 3.96 | 0.50 | <0.001 |
| GSH-px (U/mL) | 10.01 ± 0.12 | 7.05 ± 0.62** | 8.14 ± 1.09 | 9.80 ± 0.25 | 10.20 ± 0.20 | 0.40 | 0.001 |
Significant Tukey's post hoc differences compared with controls are indicated by asterisks (**P < 0.01 and *P < 0.05) and r 2 is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; SOD: superoxide dismutase; GSH-Px: glutathione peroxidase; CAT: catalase; GSH: reduced glutathione; GSSG: oxidized glutathione; MDA: malondialdehyde.