Table 3.
Effects of different doses of methylsulfonylmethane (MSM) on the levels of reduced glutathione (GSH) and disulfide-oxidized glutathione (GSSG) and MDA in rats with monocrotaline- (MCT-) induced pulmonary hypertension.
| Control | MCT-induced pulmonary hypertension groups, MSM (mg/kg/day) | ||||||
|---|---|---|---|---|---|---|---|
| 0 | 100 | 200 | 400 | r 2 | P | ||
| GSH (nmol/mL) | 543.54 ± 16.22 | 347.33 ± 41.54* | 551.65 ± 93.28 | 695.95 ± 106.36 | 774.62 ± 45.62 | 0.41 | <0.01 |
| GSSG (nmol/mL) | 50.71 ± 2.17 | 76.19 ± 6.51* | 62.98 ± 9.36 | 59.05 ± 4.80 | 51.31 ± 2.41 | 0.26 | 0.01 |
Significant Tukey's post hoc differences compared with controls are indicated by asterisks (**P < 0.01 and *P < 0.05) and r 2 is the regression coefficient of the dose-response effect. MCT: monocrotaline; MSM: methylsulfonylmethane; SOD: superoxide dismutase; GSH-Px: glutathione peroxidase; CAT: catalase; GSH: reduced glutathione; GSSG: oxidized glutathione; MDA: malondialdehyde.