. Author manuscript; available in PMC: 2012 Oct 23.

Published in final edited form as: J Invest Dermatol. 2010 Feb 11;130(6):1685–1696. doi: 10.1038/jid.2010.5

Table 2. Expression patterns of melanocyte-specific genes after UVA and/or UVB exposure.

Heat maps were generated on ratios transformed to log base 2 (colors are based on a maximum of 3, a minimum of −1.5). A gene is considered to be significantly differentially expressed (“Discriminatory for”) between treatment (i.e., SSR, UVA, or UVB) and control (denoted as “0”) if its corresponding Storey adjusted p-value is <0.05.

		median (log2 ratio)			ANOVA		Discriminatory for

Melanocytes	Pigmentary Disease/Function	SSR	UVA	UVB	p-value	p-value (FDR)	SSR vs O	UVA vs O	UVB vs O
Pmel17/SILV^IHC	melanosome structure/unknown	2.882	0.987	2.574	0.00000	0.00011	X		X
TYRP1^IHC	melanosome function/OCA3	2.871	0.523	2.105	0.00000	0.00013	X		X
TYR ^IHC	melanosome function/OCA1	2.487	0.748	2.179	0.00003	0.00035	X		X
MART1^IHC	melanosome structure/unknown	2.405	0.896	2.164	0.00000	0.00009	X		X
KIT ^IHC	receptor for SCF/UVB melanosis, vitiligo	2.317	0.558	1.493	0.00001	0.00014	X		X
OA1/GPR143	receptor for ???/Ocular albinism type 1	2.222	0.891	1.952	0.00002	0.00025	X		X
MLPH	melanosome transport/Griscelli Syndrome	2.163	0.642	2.067	0.00000	0.00012	X		X
EDNRB^IHC	receptor for ET1/UVB melanosis, lentigo senilis	2.144	0.611	1.639	0.00000	0.00011	X		X
DCT ^IHC	melanogenic enzyme/unknown	2.104	0.839	1.307	0.00005	0.00049	X		X
PAX3	transcription factor, Waardenburg syndrome	2.048	0.660	1.582	0.00005	0.00052	X		X
SOX10	transcription factor/melanocyte function	1.604	0.614	1.281	0.00001	0.00015	X		X
P	melanosome function/OCA2	0.966	0.278	0.669	0.01168	0.01804			X
MC1R	receptor for α MSH/skin & hair phenotype	0.857	0.428	1.202	0.00025	0.00146			X
MITF ^IHC	transcription factor/melanocyte function	0.792	0.160	0.759	0.00293	0.00722			X
MATP/SLC45A2	melanosome function/OCA4	0.657	0.262	1.158	0.00125	0.00414			X
WIF1	melanocyte function/Wnt signaling	0.560	0.211	0.937	0.00063	0.00266			X
LYST	Melanosome structure/Chediak Higashi syndrome	0.285	0.092	0.055	0.51243	0.19738
MyoVa	melanosome transport/Griscelli syndrome	0.284	0.363	−0.660	0.00066	0.00275			X
SOX9	transcription factor/melanocyte function	0.226	−0.111	0.107	0.77804	0.25692
MET	receptor for HGF/UVA melanosis	0.208	−0.080	−0.202	0.04751	0.04457
FGFR^IHC	receptor for bFGF/melanocyte growth	0.154	−0.127	−0.151	0.50786	0.19625
LRP6	melanocyte function/Wnt signaling	0.089	0.156	0.142	0.53970	0.20359			X
FZL	melanocyte function/Wnt signaling	−0.008	−0.621	0.093	0.00200	0.05473
RAB27a	melanosome transport/Griscelli syndrome	−0.040	−0.149	−0.248	0.00060	0.00258			X
SLC7A11 ^IHC	solute carrier/melanin switching	−0.046	0.493	−1.082	0.00132	0.00429			X
NGF-R	receptor for NGF	−0.155	−0.156	−0.047	0.39043	0.16614
GSF2RA	receptor for GM-CSF	−0.867	−0.071	−1.020	0.00000	0.00007	X		X

^IHC

validated by Immunohistochemistry