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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Dec 19;1822(5):815–821. doi: 10.1016/j.bbadis.2011.12.008

Fig. 1. Peroxynitrite modulates central sensitization through a variety of mechanisms.

Fig. 1

Peroxynitrite (PN) formed within the periphery, the spinal cord, and in supraspinal areas modulates central sensitization associated with pain of several etiologies. Pathways known to be potentially impacted as a result of overt formation of PN are depicted.