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. Author manuscript; available in PMC: 2012 Oct 23.
Published in final edited form as: Eur J Immunol. 2011 Aug 30;41(10):2987–2996. doi: 10.1002/eji.201141666

Figure 2.

Figure 2

Increasing the percentage of IFN-γ+IL-10+ cells transferred reduces EAE severity. Myelin-specific Th1 effector cells were generated and restimulated with Ag alone or in combination with TGF-β for a second (2°), third (3°), or fourth (4°) stimulation. A, After each round of stimulation, cells were analyzed by flow cytometry for IFN-γ and IL-10. Percentages shown are from the CD4+CD44+ gate. B-D, Cells collected in (A) were transferred into mice and EAE disease course and survival were monitored. Data are representative (A, D) or combined (B, C) from three independent experiments.