Body weight changes during Nphx/DOCA-NaCl/Ang II treatment. A. Average body weight of EP1+/+ (N=50) and EP1−/− mice (N=22) throughout the duration of the experiment. Body weight increased in EP1+/+ mice, but not EP1−/− mice, following Ang II administration. Average body weight declined at approximately five days post-Ang II due to mortality in the subset of mice which gained the most weight (open symbols, EP1−/−; closed symbols, EP1+/+). B. Fraction water weight 5 days post-angiotensin II administration. The fraction water weight was significantly greater in EP1+/+ mice, as compared to EP1−/− mice, P = 0.0138.