Fig. 6.

Nucleic acid substitution patterns for each patient over all sequence groups. Notation used for structures is identical to that in Fig. 1. Sequence groups were defined in Tables 4–10. Arrows point to substitutions. Substitutions are indicated using the notation “nucleic acid substitution:group number.” In some cases a substitution occurred over multiple groups and the group numbers are separated with a comma. An “X” indicates the loss and a “∧” indicates the addition of a nucleic acid. Substitutions that would potentially alter the structure are shown in red. Patient IV contained significant variation in stomach tissue (Group 6) from other sequences in the data set. These substitutions are highlighted in green. Patient DY also contained significant variation in a subset of liver sequences (Group 3) and these are also highlighted in green. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.)