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. 2012 Oct 22;209(11):1985–2000. doi: 10.1084/jem.20111665

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© 2012 Croci et al.

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Figure 1. — Gal-1 expression is a hallmark of KS. (A and B) Gal-1 transcript profile of mouse mECK36 KS tumors and human AIDS-KS compared with normal skin (Array data were obtained from Mutlu et al., 2007 and from Wang et al., 2004). (C) Left, qRT-PCR analysis of Gal-1 mRNA in mECK36 KS tumors and normal skin. Results are the mean ± SEM of three independent experiments. Right, confocal microscopy of mECK36 tumors stained for Gal-1 and LANA. Data are representative of three independent experiments. (D) Left, immunoblot of Gal-1 in KS-Imm cells. Right, flow cytometry of Gal-1 in permeabilized KS cells. Data are representative of six experiments. (E) ELISA of Gal-1 secretion by KS cells and HUVEC. Data are the mean ± SEM of three independent experiments. (F and G) Immunohistochemical analysis of human benign vascular lesions (n = 26) and primary KS tumors (n = 15) stained with anti–Gal-1 polyclonal Ab or with H&E. Data are the mean ± SEM (F) .Representative micrographs are shown (G). (C, E, and F) **, P < 0.01; ***, P < 0.001.