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. 2012 Oct 22;209(11):1907–1917. doi: 10.1084/jem.20112744

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© 2012 Jeelall et al.

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Figure 2. — CARD11 mutation induces Blimp1-dependent plasma cell differentiation and autoantibody production. (a) Flow cytometric analysis of splenocytes 9 d after transplantation of Prdm1^+/+ or Prdm1^−/− B cells, or no B cells, into Rag1-deficient recipients. The top panels show the percentage of transplanted IgM⁺ B cells in the spleen. The bottom panels are gated on the transplanted B cells and show the percentage of total EGFP⁺ cells and the proportion of these cells that are either EGFP⁺ CD19⁺ B cells or EGFP⁺ CD19⁻ plasmablasts. (b) Fold increase in numbers of EGFP⁺ B cells normalized to the number of EV-expressing Prdm1^+/+ B cells detected at day 9 after transfer. (c) Mean number and SEM of EGFP⁺ CD19⁺ B cells or EGFP⁺ CD19⁻ plasmablasts in the spleen (n = 3 mice per group and time) on the indicated days after transplantation (one-way ANOVA: P < 0.0001). (d) Amount of anti-HEL IgM relative to a standard reference serum from an Ig transgenic mouse, measured by ELISA in serum from transgenic and HEL transgenic mice 11 d after transplantation of HEL-specific B cells transduced with the indicated vectors (n = 3 mice per group; one-way ANOVA: P < 0.0001).