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. 2012 Oct 22;209(11):1907–1917. doi: 10.1084/jem.20112744

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© 2012 Jeelall et al.

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Figure 3. — IKK-β activating mutation does not switch self-reactive B cell death into proliferation. (a) Number of viable EGFP⁺ or EGFP⁻ B cells in tissue culture without antigen or anti-CD40 for 3 d, expressed as a percentage of the starting number on day 3. Numbers are mean ± SEM of three independent cultures, and data are representative of five independent experiments. (b) Number of EGFP⁺ B cells transplanted into each mouse (input). (c) Number (mean ± SEM; n = 3 per group) of EGFP⁺ HEL-binding IgM^a+ B cells in the spleen of Rag1-deficient nontransgenic or HEL transgenic mice, 11 d after transplantation of Ig transgenic B cells transduced with vectors encoding the indicated proteins (one-way ANOVA: P = 0.0080).