Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mechanism to maintain a high fibrinolytic potential on VECs and its modification by PAI-1. Secreted- and retained-tPA readily activates cell-bound plasminogen on VECs (lower right), which amplifies plasminogen accumulation to newly exposed C-terminal lysine by plasmin-dependent cleavage of cell surface proteins (upper right). PAI-1 suppresses these mechanisms by removing retained tPA from VECs by forming high molecular weight complex (left).
