Table 3.
Multivariate Cox regression analysis of predictors of mortality among Children on ART at Felege Hiwot referral hospital, January 1st, 2006 - March 31st, 2011
|
Variable |
Survival status |
Crude HR (95% CI) |
Adjusted HR (95% CI) |
|
|---|---|---|---|---|
| Died | Censored | |||
|
Age |
|
|
|
|
| < 1yr |
4 |
18 |
1 |
|
| 1-5 yr |
10 |
187 |
0.25(0.08, 0.79) |
* |
| 5 -15 yr |
27 |
303 |
0.38(0.13, 1.09) |
* |
|
Sex |
|
|
|
|
| Male |
17 |
269 |
0.66 (0.35, 1.22) |
* |
| Female |
24 |
239 |
1 |
|
|
OIs |
|
|
|
|
| Yes |
20 |
145 |
2.01 (1.09, 3.72) |
* |
| No |
21 |
363 |
1 |
|
|
Cotrimoxazole preventive therapy |
|
|
|
|
| Yes |
8 |
279 |
1 |
1 |
| No |
33 |
229 |
4.89(2.26,10.59) |
4.74 (2.17, 10.34) |
|
Developmental history |
|
|
|
|
| Appropriate |
34 |
497 |
1 |
1 |
| Delayed/regressing |
7 |
11 |
10.13(4.43, 23.1) |
6.31(2.52, 15.83) |
|
WHO staging |
|
|
|
|
| I/II |
8 |
165 |
0.28(0.11, 0.72) |
* |
| III |
23 |
294 |
0.43(0.21, 0.91) |
* |
| IV |
10 |
49 |
1 |
|
|
Haemoglobin (n = 520) |
|
|
|
|
| <10gm/dl |
15 |
88 |
2.87(1.5, 5.5) |
2.44 (1.26, 4.73) |
| ≥10gm/dl |
24 |
393 |
1 |
1 |
|
Nutritional status |
|
|
|
|
| Underweight |
39 |
414 |
3.89(0.94, 16.1) |
* |
| Normal |
2 |
94 |
1 |
|
|
CD4 cell count |
|
|
|
|
| CD4 count below the threshold |
30 |
259 |
2.55(1.28, 5.1) |
2.24(1.07, 4.69) |
| CD4 count above the threshold | 11 | 249 | 1 | 1 |
* Non significant from the multivariate Cox regression (Backward LR method).