Table 1.

Studies on signaling pathway of CREB activation by Group I mGluRs in cingulate cortex

Signaling molecules	Manipulations	Effects on CREB phosphorylation induced by DHPG	References
AC1	AC1 knockout	Reduced	38
PKA	PKA inhibitor	Reduced	38
CaMKIV	CaMKIV knockout	Reduced	38
	CaMK inhibitor	Reduced	37
	CaMKIV over expression	Enhanced	37