Table 2.
Association ofCDKN2Amethylation and clinico-pathological features in colorectal cancers (n = 422)
|
Feature |
|
CDKN2AN(%) |
P-value |
|
|---|---|---|---|---|
| Negative (335; 79.4%) | Methylated (87; 20.6%) | |||
| Age |
Mean (range) |
69.3 (37–95) |
68.8 (39–89) |
0.7292 |
| Tumor size |
Mean (range) |
49.3 (5–160) |
53.5 (4–170) |
0.1265 |
| Tumor location |
Left-sided |
232 (69.5) |
40 (46.5) |
<0.0001 |
| |
Right-sided |
102 (30.5) |
46 (53.5) |
|
| Gender |
Female |
181 (54.0) |
48 (55.2) |
0.849 |
| |
Male |
154 (46.0) |
39 (44.8) |
|
| Histological subtype |
Non-mucinous |
19 (5.7) |
11 (12.6) |
0.0209 |
| |
Mucinous |
316 (94.3) |
76 (87.4) |
|
| Tumor grade |
G1-2 |
317 (96.7) |
74 (85.1) |
<0.0001 |
| |
G3 |
11 (3.4) |
13 (14.9) |
|
| pT classification |
pT1-2 |
75 (22.9) |
14 (16.1) |
0.1711 |
| |
pT3-4 |
253 (77.1) |
73 (83.9) |
|
| pN classification |
pN0 |
180 (55.9) |
37 (43.0) |
0.0335 |
| |
pN1-2 |
142 (44.1) |
49 (57.0) |
|
| Vascular invasion |
Absent |
238 (72.6) |
54 (62.1) |
0.0568 |
| |
Present |
90 (27.4) |
33 (37.9) |
|
| Invasive margin |
Pushing |
101 (30.9) |
21 (24.4) |
0.242 |
| |
Infiltrating |
226 (69.1) |
65 (75.6) |
|
| Peritumoral lymphocytic inflammation |
Absent |
251 (76.5) |
66 (75.9) |
0.897 |
| |
Present |
77 (23.5) |
21 (24.1) |
|
|
KRAS (codon 12/13) |
Wild-type |
227 (69.2) |
58 (72.5) |
0.565 |
| |
Mutation |
101 (30.8) |
22 (27.5) |
|
|
BRAF (codon V600E) |
Wild-type |
287 (94.1) |
53 (68.8) |
<0.0001 |
| |
Mutation |
18 (5.9) |
24 (31.2) |
|
| MSI status |
MSS/MSI-L |
272 (86.6) |
62 (76.5) |
0.0252 |
| MSI-H | 42 (13.4) | 19 (23.5) | ||