Table 4.
Association ofCDKN2Amethylation and clinico-pathological features stratified by microsatellite instability (MSI) status
|
Feature |
|
CDKN2A in MSS/MSI-L (n;%) |
P-value |
CDKN2A in MSI-H (n;%) |
P-value |
||
|---|---|---|---|---|---|---|---|
| |
|
Negative |
Positive |
|
Negative |
Positive |
|
| (n = 272; 81.4%) | (n = 62; 18.6%) | (n = 42; 68.9%) | (n = 19; 31.2%) | ||||
| Age |
Mean (range) |
69.5 (40–95) |
69.9 (44–88) |
0.788 |
68.4 (45–87) |
68.2 (50–89) |
0.9897 |
| Tumor size |
Mean (range) |
48.0 (5–130) |
49.8 (4–105) |
0.523 |
54.9 (19–160) |
62.8 (15–170) |
0.3737 |
| Tumor location |
Left-sided |
193 (71.2) |
34 (54.8) |
0.0125 |
24 (57.1) |
4 (22.2) |
0.013 |
| |
Right-sided |
78 (28.8) |
28 (45.2) |
|
18 (42.9) |
14 (77.8) |
|
| Gender |
Female |
149 (54.8) |
34 (54.8) |
0.9932 |
20 (47.6) |
10 (52.6) |
0.7169 |
| |
Male |
123 (45.2) |
28 (45.2) |
|
22 (52.4) |
9 (47.4) |
|
| Histological subtype |
Non-mucinous |
253 (93.0) |
54 (87.1) |
0.1142 |
39 (92.9) |
16 (84.2) |
0.2863 |
| |
Mucinous |
16 (5.9) |
8 (12.9) |
|
3 (7.1) |
2 (10.5) |
|
| Tumor grade |
G1-2 |
261 (98.1) |
54 (87.1) |
<0.0001 |
37 (88.1) |
14 (73.7) |
0.2608 |
| |
G3 |
5 (1.9) |
8 (12.9) |
|
5 (11.9) |
5 (26.3) |
|
| pT classification |
pT1-2 |
59 (22.1) |
13 (21.0) |
0.8354 |
12 (28.6) |
0 (0.0) |
0.0093 |
| |
pT3-4 |
207 (77.8) |
49 (79.0) |
|
30 (71.4) |
19 (100.0) |
|
| pN classification |
pN0 |
140 (53.4) |
23 (37.1) |
0.0207 |
26 (66.7) |
10 (52.6) |
0.3012 |
| |
pN1-2 |
122 (46.6) |
39 (62.9) |
|
13 (33.3) |
9 (47.4) |
|
| Vascular invasion |
Absent |
186 (69.9) |
37 (59.7) |
0.1193 |
35 (83.3) |
11 (57.9) |
0.0326 |
| |
Present |
80 (30.1) |
25 (40.3) |
|
7 (16.7) |
8 (42.1) |
|
| Invasive margin |
Pushing |
69 (26.0) |
12 (19.7) |
0.2996 |
26 (61.9) |
6 (31.6) |
0.0281 |
| |
Infiltrating |
196 (74.0) |
49 (80.3) |
|
16 (38.1) |
13 (68.4) |
|
| Peritumoral lymphocytic inflammation |
Absent |
211 (79.3) |
51 (82.3) |
0.6037 |
27 (64.3) |
13 (68.4) |
0.7529 |
| |
Present |
55 (20.7) |
11 (17.7) |
|
15 (35.7) |
6 (31.6) |
|
|
KRAS (codon 12/13) |
Wild-type |
185 (69.0) |
41 (68.3) |
0.9161 |
26 (65.0) |
14 (93.3) |
0.0356 |
| |
Mutation |
83 (31.0) |
19 (31.7) |
|
14 (35.0) |
1 (6.7) |
|
|
BRAF (codon V600E) |
Wild-type |
245 (96.8) |
42 (75.0) |
<0.0001 |
30 (79.0) |
8 (44.4) |
0.0098 |
| Mutation | 8 (3.2) | 14 (25.0) | 8 (21.0) | 10 (55.6) | |||