Table 11.
Markers of catabolism and bone status
|
Marker |
N |
Group |
Day |
|
p-level |
||
|---|---|---|---|---|---|---|---|
| 0 | 7 | 28 | |||||
|
BUN (mg/dl) |
11 |
KA-L |
16.0 ± 5.3 |
15.3 ± 4.9 |
15.6 ± 5.1 |
Group |
0.89 |
| |
12 |
KA-H |
16.1 ± 3.3 |
16.6 ± 3.9 |
16.6 ± 3.6 |
Time |
0.70 |
| |
12 |
CrM |
16.4 ± 3.2 |
15.7 ± 2.7 |
16.1 ± 4.7 |
G x T |
0.75 |
|
Creatinine |
11 |
KA-L |
1.04 ± 0.08 |
1.08 ± 0.11 |
1.13 ± 0.10† |
Group |
0.07 |
| (mg/dl) |
12 |
KA-H |
1.07 ± 0.14 |
1.23 ± 0.18†* |
1.26 ± 0.13†* |
Time |
0.001 |
| |
12 |
CrM |
1.11 ± 0.19 |
1.28 ± 0.20†* |
1.23 ± 0.15†* |
G x T |
0.03 |
|
BUN:CRN Ratio |
11 |
KA-L |
15.5 ± 5.1 |
14.5 ± 5.6 |
14.1 ± 5.6 |
Group |
0.83 |
| |
12 |
KA-H |
15.1 ± 3.4 |
13.7 ± 3.4 |
13.3 ± 3.4 |
Time |
0.001 |
| |
12 |
CrM |
15.2 ± 3.7 |
12.4 ± 2.6 |
13.2 ± 3.8 |
G x T |
0.24 |
|
AST (U/L) |
11 |
KA-L |
25.4 ± 9.6 |
26.5 ± 8.4 |
29.5 ± 12.9 |
Group |
0.62 |
| |
12 |
KA-H |
27.3 ± 10.5 |
25.6 ± 8.3 |
32.0 ± 12.0 |
Time |
0.02 |
| |
12 |
CrM |
24.9 ± 7.9 |
23.8 ± 7.5 |
26.3 ± 7.8 |
G x T |
0.70 |
|
ALT (U/L) |
11 |
KA-L |
21.5 ± 11.2 |
23.5 ± 14.2 |
28.7 ± 19.4 |
Group |
0.50 |
| |
12 |
KA-H |
24.1 ± 15.6 |
22.3 ± 12.2 |
27.3 ± 9.1 |
Time |
0.05 |
| |
12 |
CrM |
21.3 ± 7.34 |
18.0 ± 4.2 |
21.3 ± 5.5 |
G x T |
0.48 |
|
Total Protein (g/dl) |
11 |
KA-L |
7.4 ± 0.6 |
7.4 ± 0.4 |
7.4 ± 0.4 |
Group |
0.87 |
| |
12 |
KA-H |
7.3 ± 0.3 |
7.3 ± 0.3 |
7.3 ± 0.2 |
Time |
0.88 |
| |
12 |
CrM |
7.3 ± 0.2 |
7.3 ± 0.2 |
7.4 ± 0.3 |
G x T |
0.84 |
|
TBIL (mg/dl) |
11 |
KA-L |
0.84 ± 0.7 |
0.75 ± 0.3 |
0.76 ± 0.3 |
Group |
0.60 |
| |
12 |
KA-H |
0.88 ± 0.5 |
0.89 ± 0.5 |
0.77 ± 0.4 |
Time |
0.90 |
| |
12 |
CrM |
0.63 ± 0.2 |
0.71 ± 0.2 |
0.77 ± 0.2 |
G x T |
0.26 |
|
Bone Mineral |
11 |
KA-L |
2,517 ± 404 |
2,503 ± 409 |
2,505 ± 398 |
Group |
0.59 |
|
Content (g) |
12 |
KA-H |
2,632 ± 457 |
2,604 ± 466 |
2,615 ± 456 |
Time |
0.49 |
| |
12 |
CrM |
2,446 ± 344 |
2,456 ± 0.2 |
2,441 ± 351 |
G x T |
0.66 |
|
Albumin (g/dl) |
11 |
KA-L |
4.80 ± 0.3 |
4.81 ± 0.4 |
4.81 ± 0.2 |
Group |
0.95 |
| |
12 |
KA-H |
4.83 ± 0.2 |
4.74 ± 0.2 |
4.78 ± 0.1 |
Time |
0.73 |
| |
12 |
CrM |
4.82 ± 0.2 |
4.80 ± 364 |
4.79 ± 0.2 |
G x T |
0.89 |
|
Globulin (g/dl) |
11 |
KA-L |
2.60 ± 0.4 |
2.63 ± 0.3 |
2.55 ± 0.3 |
Group |
0.90 |
| |
12 |
KA-H |
2.56 ± 0.3 |
2.58 ± 0.2 |
2.52 ± 0.3 |
Time |
0.85 |
| |
12 |
CrM |
2.55 ± 0.3 |
2.54 ± 0.2 |
2.62 ± 0.3 |
G x T |
0.42 |
|
Alb:Glob Ratio |
11 |
KA-L |
1.88 ± 0.3 |
1.85 ± 0.2 |
1.90 ± 0.2 |
Group |
0.98 |
| |
12 |
KA-H |
1.90 ± 0.1 |
1.86 ± 0.2 |
1.91 ± 0.1 |
Time |
0.70 |
| |
12 |
CrM |
1.88 ± 0.2 |
1.90 ± 0.2 |
1.84 ± 0.2 |
G x T |
0.45 |
|
Calcium (mg/dl) |
11 |
KA-L |
9.87 ± 0.5 |
9.85 ± 0.5 |
9.76 ± 0.4 |
Group |
0.42 |
| |
12 |
KA-H |
9.83 ± 0.2 |
9.81 ± 0.4 |
9.84 ± 0.2 |
Time |
0.51 |
| |
12 |
CrM |
9.77 ± 0.3 |
9.63 ± 0.4 |
9.67 ± 0.3 |
G x T |
0.76 |
|
ALK (U/L) |
11 |
KA-L |
82.0 ± 16.4 |
84.1 ± 20.5 |
83.9 ± 17.0 |
Group |
0.88 |
| |
12 |
KA-H |
81.1 ± 29.7 |
83.8 ± 30.3 |
87.1 ± 27.6 |
Time |
0.29 |
| 12 | CrM | 78.9 ± 20.7 | 80.6 ± 26.4 | 78.8 ± 23.1 | G x T | 0.65 | |
Values are means ± standard deviations. Data were analyzed by MANOVA with repeated measures. Greenhouse-Geisser time and group x time (G x T) interaction p-levels are reported with univariate group p-levels. † represents p < 0.05 difference from baseline. * represents p < 0.05 difference from KA-L.