Figure 4. Plasma concentration of K-134 and cilostazol in a rat arteriovenous shunt model.

Blood samples were taken at 0.5, 1.5, 3.5, and 5.5 h after oral drug administration in a rat arteriovenous shunt model under the same conditions as described in Table 1, and plasma concentrations of K-134 (A) and cilostazol (B) were determined by HPLC. Values represent means ± SEM of the plasma concentration (µM) (n = 6). (C) The dose-response curve between the area under the plasma drug concentration-time curve from time 1.5 h to 5.5 h (AUC_{1.5–5.5 h}) and the inhibition rate of arteriovenous shunt thrombus formation. AUC_{1.5–5.5 h} was estimated from data of Fig. 4A and 4B.