Table 1. Inhibitory effects of PDE3 inhibitors on arteriovenous shunt thrombus formation.

	Control	K-134 (mg/kg)			Cilostazol (mg/kg)
		3	10	30	10	30	100
Occluded/Total	11/12	9/12	4/12*	4/12*	7/12	4/12*	3/12**
Occlusion (%)	92	75	33	33	58	33	25
Inhibition (%)	N/A	18	64	64	37	64	73
ED50 (mg/kg)	N/A	11			18

K-134 and cilostazol were administered to rats in a single dose 90 min before creation of the arteriovenous shunt. K-134 at concentrations above 10 mg/kg and cilostazol at concentrations above 30 mg/kg decreased the incidence of occlusive arteriovenous shunt thrombi (%) (*P<0.05, *P<0.01, two-tailed Fisher's exact test with Bonferroni's procedure, n = 12).