Table 2. Absolute metabolite concentrations and metabolite/creatine peak area ratios of each volume of interest (VOI).

VOI	Metabolites	Metabolite/Cr Peak Area Ratios and Absolute Concentrations#
		SAD(mean±SD)	control(mean±SD)	t value	P value
Left DLPFC	NAA *	15.573±1.571	16.194±1.560	−0.842	0.412
	Cho *	2.373±0.597	2.757±0.657	−1.296	0.213
	Cr *	11.217±1.297	13.392±2.220	−2.539	0.022
	NAA/Cr	1.398±0.160	1.230±0.167	2.186	0.044
	Cho/Cr	0.209±0.034	0.207±0.034	0.149	0.883
ACC	NAA *	14.839±2.081	15.173±3.564	−0.236	0.817
	Cho *	4.186±1.057	3.710±0.929	0.942	0.362
	Cr *	14.737±3.223	14.836±2.276	−0.069	0.946
	NAA/Cr	1.034±0.184	1.019±0.159	0.176	0.863
	Cho/Cr	0.292±0.080	0.253±0.063	1.060	0.307
Left Putamen	NAA	13.398±1.552	12.871±1.612	0.719	0.482
	Cho	2.596±0.483	3.006±0.664	−1.565	0.136
	Cr	13.730±1.630	13.834±1.769	−0.132	0.896
	NAA/Cr	0.987±0.158	0.950±0.207	0.438	0.667
	Cho/Cr	0.191±0.038	0.216±0.027	−1.595	0.129
Right Putamen	NAA	12.310±1.786	12.809±1.692	−0.608	0.551
	Cho	2.164±1.320	2.557±0.735	−0.779	0.447
	Cr	13.303±2.234	13.913±2.063	−0.602	0.556
	NAA/Cr	0.947±0.198	0.931±0.138	0.191	0.851
	Cho/Cr	0.154±0.078	0.184±0.047	−0.977	0.343
Left Thalamus	NAA	14.960±2.404	14.209±4.071	0.506	0.620
	Cho	2.761±0.840	2.293±0.792	1.228	0.236
	Cr	10.402±2.136	11.053±3.687	−0.487	0.633
	NAA/Cr	1.475±0.296	1.362±0.399	0.715	0.484
	Cho/Cr	0.269±0.080	0.215±0.073	1.489	0.155

^*Corrected for the partial volume effect of cerebrospinal fluid.

^#The unit of the absolute concentration is mol/kg wet weight.

Abbreviations: DLPFC-Dorsal Lateral Prefrontal Cortex; ACC-Anterior Cingulate Cortex.