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. 2012 Oct 23;7(10):e48135. doi: 10.1371/journal.pone.0048135

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© 2012 Hall et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Number of val158met met alleles showed a significant linear effect on IBS-SSS (beta = 0.17; p = .032). IBS-SSS includes abdominal pain severity, abdominal pain frequency, abdominal distention severity, dissatisfaction with bowel habits, and disruption of quality of life. Change in IBS-SSS = (IBS-SSS at baseline – IBS-SSS at 3-weeks). Regression model included COMT genotype (number of met alleles) and baseline IBS-SSS. Error bars indicate the standard error of the mean. N = 104.