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. 2012 Aug 9;40(19):9903–9916. doi: 10.1093/nar/gks735

Figure 1.

Figure 1.

Putative SR and SR-like proteins in P. falciparum. (A) Schematic representation of the domain structure of P. falciparum putative proteins that are predicted to contain RNA Recognition Motif (RRM, ellipses) and SR domain (RS, rectangles). Pervious predictions of homologs are shown with references (B) A phylogenetic tree built with the Neighbor-Joining algorithm based on the entire amino acid sequence of the predicted P. falciparum SR proteins. As shown the closest homologs of SRSF1 are PfSR1 (PFE0865c) and PF10_0217, respectively. (C) Homology modeling of the first RRM of PfSR1 based on the human SRSF1 RRM1. The crystal structure of the human SRSF1 was retrieved from the Protein Data Bank (http://www.rcsb.org/pdb/home/home.do, PDB-1x4aA). The two RRMs have 51% identity over 80 amino acids. The Z-score for the model quality calculated using ProSA (https://prosa.services.came.sbg.ac.at/prosa.php) is 5.5.