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The methyltransferase activity of PRMT6 is required to bypass Ras-induced senescence. Rescue of RasV12-induced senescence using wild-type PRMT6 (PRMT6WT) but not a methyltransferase inactive PRMT6 (PRMT6VLD:KLA). The percent and standard deviation of SA-β-Gal-positive cells are indicated at the bottom right of each panel. Data represent three independent measurements done with cells fixed 14 day post-selection.
