Table 1.

dKDM5/LID depletion downregulates expression of target genes

PDE	Average fold-change expression	Upregulated genes	Downregulated genes	Down/up ratio	P-value
>0.95	−2.91	1	10	10	0.0117
>0.90	−1.49	11	31	2.82	0.0029
>0.80	−1.26	34	85	2.50	P <0.0001
>0.70	−1.16	71	133	1.87	P <0.0001
>0.60	−1.11	110	178	1.62	P <0.0001
>0.50	−1.07	175	235	1.34	P = 0.0035

The number of dKDM5/LID target genes upregulated and downregulated in lid^RNAi flies is presented for several cut-offs on the PDE (see ‘Materials and Methods’ section for details). The down/up ratio and the average fold-change expression are indicated. Statistical significance of the differences is also indicated (Binomial test for 50/50 up/down proportions).