Abstract
Candida albicans has been shown to stimulate infection in mice by a number of bacteria. Mice inoculated intraperitoneally with as little as 500 colony-forming units of Staphylococcus aureus along with a nonlethal dose of 10(8) colony-forming units of C. albicans (one-third the dose causing 50% mortality in 7 days) developed widespread staphylococcal infection. S. aureus injected alone at that or considerably higher doses did not establish infection. Phage typing methods demonstrated that the staphylococcal infection was due to the bacterial organisms originally injected. A minimum dose of C. albicans between 1.1 X 10(5) and 1.1 X 10(7) colony-forming units was necessary for the amplification of virulence of S. aureus to take place. Serratia marcescens and Streptococcus faecalis inoculated intraperitoneally at small nonlethal doses could also be recovered from blood and tissues 5 days after animals were dually injected with C. albicans but not from animals which were inoculated with the same amounts of these bacteria alone.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Budtz-Jorgensen E. Denture stomatitis. 3. Histopathology of trauma- and candida-induced inflammatory lesions of the palatal mucosa. Acta Odontol Scand. 1970 Nov;28(5):551–579. doi: 10.3109/00016357009058583. [DOI] [PubMed] [Google Scholar]
- Budtz-Jörgensen E., Stenderup A., Grabowski M. An epidemiologic study of yeasts in elderly denture wearers. Community Dent Oral Epidemiol. 1975 May;3(3):115–119. doi: 10.1111/j.1600-0528.1975.tb00291.x. [DOI] [PubMed] [Google Scholar]
- Carlson E. Synergistic effect of Candida albicans and Staphylococcus aureus on mouse mortality. Infect Immun. 1982 Dec;38(3):921–924. doi: 10.1128/iai.38.3.921-924.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Durack D. T. Opportunistic infections and Kaposi's sarcoma in homosexual men. N Engl J Med. 1981 Dec 10;305(24):1465–1467. doi: 10.1056/NEJM198112103052408. [DOI] [PubMed] [Google Scholar]
- GALE D., SANDOVAL B. Response of mice to the inoculations of both Candida albicans and Escherichia coli. I. The enhancement phenomenon. J Bacteriol. 1957 May;73(5):616–624. doi: 10.1128/jb.73.5.616-624.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hamilton J. R., Overall J. C., Glasgow L. A. Synergistic effect on mortality in mice with murine cytomegalovirus and Pseudomonas aeruginosa, Staphylococcus aureus, or Candida albicans infections. Infect Immun. 1976 Oct;14(4):982–989. doi: 10.1128/iai.14.4.982-989.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KEENEY E. L. Candida asthma. Ann Intern Med. 1951 Jan;34(1):223–226. doi: 10.7326/0003-4819-34-1-223. [DOI] [PubMed] [Google Scholar]
- Larsen B., Galask R. P. Vaginal microbial flora: composition and influences of host physiology. Ann Intern Med. 1982 Jun;96(6 Pt 2):926–930. doi: 10.7326/0003-4819-96-6-926. [DOI] [PubMed] [Google Scholar]
- MAIBACH H. I., KLIGMAN A. M. The biology of experimental human cutaneous moniliasis (Candida albicans). Arch Dermatol. 1962 Feb;85:233–257. doi: 10.1001/archderm.1962.01590020073009. [DOI] [PubMed] [Google Scholar]
- MANKIEWICZ E., LIVAK M. Effect of Candida albicans on the evolution of experimental tuberculosis. Nature. 1960 Jul 16;187:250–251. doi: 10.1038/187250a0. [DOI] [PubMed] [Google Scholar]
- PIERRE R., CAHN J. Efectos de la serotonina (5 hidroxitriptamina) en anestesia; estudio farmacológico. Rev Esp Anestesiol. 1956 Jan;3(1):33–36. [PubMed] [Google Scholar]