Table 1.

IDHP activity at VGCC and MDR-1.

IDHP	R1	R2	VGCC Ki (nM)	VGCC Patch Clamp (M)	Ref.	MDR-1 (% inh.)
1a	CH3	C6H5	13.9		12,13,15	48.9
1b	CH3	o-MeO-C6H4		17.1	19	32.8
1c	CH3	2-MeO-5-Cl-C6H3		6.86	19	15.0
1d	CH3	o-Cl-C6H4		9.68	19	10.9
1e	CH3	m-Cl-C6H4		1.98	19	26.8
1f	CH3	p-Cl-C6H4		1.31	19	11.7
1g	i-Pr	C6H5	a		14	38.4
1h	C6H5CH2CH2	C6H5	55.3		18	27.6
1i	p-Biphenyl-CH2CH2	CH3	8.69		18	18.6
1j	1-naphthyl CH2CH2	CH3	4.1	0.47	18,19	19.0
1k	m-Br-C6H5CH2(CH3)CH	CH3			this work	61.2
1l	1-naphthyl CH2(CH3)CH	CH3			this work	38.3

a weak vasodilator in the Langendorff perfused heart assay.