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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Curr Opin Cell Biol. 2012 Jul 6;24(5):620–627. doi: 10.1016/j.ceb.2012.05.014

Figure 2. Parallels between biophysical and structural data.

Figure 2

The red arrows highlight the corresponding features in adhesion-based measurements and structural data. (A) Force versus distance measurements with a surface force apparatus showing cadherin adhesion at three membrane distances, indicated by the minima in the curves and outward directed arrows. (B) The strand dimer interface and orientation of trans-bonded cadherins between apposing membranes. (C) X-dimer complex between apposing cadherin interactions. The structures of the trans and X-dimers (center) are compared with cadherin binding signatures from three different biophysical measurements discussed in the text. or X-dimer (center) and different features in surface force measurements (top), AFM data (bottom left), and cell binding kinetics (bottom right).