Table 1.

Homo-dimerization affinities from AUC measurements at 25°C

Protein	Description	KA (x 104) M−1	Ref.
Xenopus C-cadherin EC1–5
WT	Wild Type	1.56	[48]
Mouse E-cadherin EC1–2
WT	Wild Type (human)	1.25	[49]
WT	Wild Type	1.04	[4]
WT	Wild Type	1.01	[16]
W2A	Strand-swap mutant	0.11
Ala-Ala N-terminal extension	Strand-swap mutant	0.12
E89A	Strand-swap mutant	0.34
Asp-Trp deletion at N-terminus	Strand-swap mutant	0.15
K14E	X-dimer mutant	1.17
K14S	X-dimer mutant	1.04
Y142R	X-dimer mutant	1.30
W2A K14E	Double mutant	monomer
W2F	Reduced strain on A*/A strand	0.41	[17]
Ala inserted between 2 and 3	Reduced strain on A*/A strand	0.07
AlaAla inserted between 2 and 3	Reduced strain on A*/A strand	0.51
E11D	Enhanced strand-swapping	1.40
P5A P6A	Swapping strand stabilization	27
P5S P6S	Swapping strand stabilization	34
P5G P6G	Swapping strand stabilization	37
P5A	Swapping strand stabilization	34
P5G	Swapping strand stabilization	21
Mouse N-cadherin EC1–2
WT	Wild Type	3.88	[4]
P5A P6A	Swapping strand stabilization	27	[17]