Table 2.
Selected pathways identified by enrichment analysis of normal epithelium versus HPV− OPC
| Database | Database ID | Description | Up/Down in HPV− OPC |
p- value |
|---|---|---|---|---|
| GO (BP) | 0007155/0022610 | Cell/biological adhesion |
|
<0.0001 |
| GO (BP) | 0006955 | Immune response |
|
0.0007 |
| GO (BP) | 0043062 | Extracellular structure organization |
|
0.0016 |
| GO (BP) | 0008544 | Epidermis development |
|
0.007 |
| GO (BP) | 0030855/0009913 | Epithelial/Epidermal cell differentiation |
|
<0.0001 |
| GO (BP) | 0009888/0060429 | Tissue/Epithelium development |
|
<0.0001 |
| GO (BP) | 0030216/0031424 | Keratinocyte differentiation/Keratinization |
|
<0.0001 |
| GO (BP) | 0006941 | Striated muscle contraction |
|
0.0004 |
| GO (BP) | 0005509 | Calcium ion binding |
|
0.0023 |
| GO (BP) | 0030414 | Peptidase inhibitor activity |
|
0.008 |
| GO (MF) | 0005201 | Extracellular matrix structural constituent |
|
0.004 |
| GO (MF) | 0005509 | Calcium ion binding |
|
0.004 |
| GO (MF) | 0008307 | Structural constituent of muscle |
|
<0.0001 |
| GO (MF) | 0005198 | Structural molecule activity |
|
0.0005 |
| KEGG | 04512 | ECM receptor interaction |
|
<0.0001 |
| KEGG | 04510 | Focal adhesion |
|
0.009 |
| KEGG | 04530 | Tight junction |
|
0.0042 |
| KEGG | 05416 | Viral myocarditis |
|
0.0042 |
| KEGG | 04260 | Cardiac muscle contraction |
|
0.0042 |
| WP | 619 | Type II interferon signaling |
|
0.002 |
| WP | 453 | Inflammatory response pathway |
|
0.002 |
| WP | 383 | Striated muscle contraction |
|
<0.0001 |
| PC | 560 | Integrin cell surface interactions |
|
0.002 |
| MSigDB (TF) | 2287 | NKX25_2 |
|
0.034 |
| MSigDB (TF) | 1876 | MEF2_02 |
|
0.023 |
| MSigDB (TF) | 1961 | TATA_01 |
|
0.023 |
| MSigDB (TF) | 2174 | P53 |
|
0.023 |
| CHR | 11177 | 4q28 |
|
0.024 |
| CHR | 11220 | 17p13 |
|
0.085 |