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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Invest Dermatol. 2012 Jul 19;133(1):31–41. doi: 10.1038/jid.2012.230

Figure 2.

Figure 2

Epidermal Wls is required for anagen. (a) Tamoxifen-mediated Cre induction regimen. (b) Relative quantities of Wls mRNA determined by qPCR from RNA isolated from dorsal skin epidermis of control and Wls K14cKO mice 5 days after induction (P32, N=5 mice). (c) Images of P37 mice shaved after induction. (d) H&E sections from control mice during anagen (P37) and catagen (P47; bar=100 μm). Wls K14cKO hair follicles at the same time points remained arrested in telogen or anagen I/II. (e) Hair cycle distribution of control and mutant mice at P37-40. (f) Wls expression in P37 control and mutant hair follicles (bar=50 μm). Scattered Wls immunoreactive cells were noted throughout the dermis but similar between control and mutant mice. (g,h) Tamoxifen was administered during second telogen prior to depilation at indicated times. (i) H&E sections from skin plucked 15 days post-depilation (15 dpd; bar=200 μm).