Table 5.
Cytokine and immune mediator concentrations in amniotic fluid by maternal age
| Mediator |
Age |
Age |
Age |
Age |
Age |
p-value |
|---|---|---|---|---|---|---|
| 19-25 | 26-30 | 31-35 | 36-40 | >40 | ||
| IL-2 (n = 66) |
5.2 |
4.6 |
4.3 |
3.8 |
3.9 |
0.97 |
| IL-4 (n = 182) |
8.3 |
6.6 |
9.0 |
9.2 |
9.7 |
0.18 |
| IL-6 (n = 156) |
879.2 |
668.9 |
738.7 |
669.2 |
832.8 |
0.97 |
| IL-8 (n = 185) |
829.5 |
551.4 |
754 |
621.0 |
552.1 |
0.45 |
| IL-10 (n = 161) |
9.1 |
7.1 |
5.8 |
5.5 |
5.1 |
0.49 |
| IL-12 (n = 161) |
5.1 |
5.8 |
4.9 |
5.3 |
5.5 |
0.94 |
| IL-15 (n = 173) |
35.8 |
31.3 |
28.0 |
12.3 |
11.5 |
0.51 |
| IL-17 (n = 66) |
32.7 |
19.3 |
19.2 |
23.4 |
21.8 |
0.46 |
| TNF- α (n = 161) |
9.3 |
11.0 |
12.1 |
13.0 |
12.1 |
0.56 |
| GRO- α (n = 184) |
629.5 |
1254.3 |
1228.1 |
663.0 |
492.9 |
0.01 |
| Pro IL1-ß (n = 157) |
19.8 |
19.5 |
16.9 |
19.4 |
17.0 |
0.48 |
| Histone (n = 161) |
0.3 |
0.2 |
0.3 |
0.3 |
0.3 |
0.83 |
| IP-10 (n = 169) |
1435.3 |
644.6 |
722.7 |
814.0 |
702.8 |
0.33 |
| MIP1-ß (n = 182) |
27.5 |
25.8 |
28.3 |
25.9 |
27.7 |
0.71 |
| MIP1- α (n = 186) | 25.6 | 25.9 | 25.7 | 24.8 | 26.0 | 0.79 |
Median biomarker concentration (pg/ml) by maternal age.