Table 1.
Patient characteristics including demographics, tumor -, and treatment features
| Overall | Definitive RT | Surgery +/− RT | p-value* | Preoperative RT | Surgery only | Postoperative RT | p-value† | |
|---|---|---|---|---|---|---|---|---|
| No of pts. | 2,431 | 1,426 (58.7) | 1,005 (41.3) | 369 (36.7) | 476 (47.4) | 160 (15.9) | ||
| Age (mean, SD), years | 66.5 (11.1) | 68.1 (11.1) | 64.2 (10.6) | <0.001 | 61.3 (9.4) | 67.0 (10.9) | 62.1 (10.3) | 0.008‡ |
| Female (n, %) | 871 (35.8) | 486 (34.1) | 385 (38.3) | 0.03 | 128 (34.7) | 199 (41.8) | 58 (36.3) | 0.09 |
| Race | ||||||||
| White | 1,577 (64.9) | 877 (61.5) | 700 (69.7) | <0.001 | 266 (72.1) | 333 (70.0) | 101 (63.1) | 0.33 |
| Black | 557 (22.9) | 369 (25.9) | 188 (18.7) | 61 (16.5) | 90 (18.9) | 37 (23.1) | ||
| Other/Unknown | 297 (12.2) | 180 (12.6) | 117 (11.6) | 42 (11.4) | 53 (11.1) | 22 (13.8) | ||
| Ethnicity | ||||||||
| Hispanic | 2,283 (93.9) | 1,330 (93.3) | 953 (94.8) | 0.11 | 14 (3.8) | 30 (6.3) | 8 (5.0) | 0.26 |
| Non-Hispanic | 148 (6.1) | 96 (6.7) | 52 (5.2) | 355 (96.2) | 446 (93.7) | 152 (95.0) | ||
| Marital Status | ||||||||
| Married | 1,279 (52.6) | 693 (48.6) | 586 (58.3) | <0.001 | 251 (68.0) | 245 (51.5) | 90 (56.3) | <0.001 |
| Other/Unknown | 1,152 (47.4) | 733 (51.4) | 419 (41.7) | 118 (32.0) | 231 (48.5) | 70 (43.8) | ||
| Tumor location | ||||||||
| Mid esophagus | 1,469 (60.4) | 948 (66.5) | 521 (51.8) | <0.001 | 208 (56.4) | 227 (47.7) | 86 (53.8) | 0.04 |
| Lower esophagus | 962 (39.6) | 478 (33.5) | 484 (48.2) | 161 (43.6) | 249 (52.3) | 74 (46.3) | ||
| Primary tumor (T) | ||||||||
| T1 | 164 (6.7) | 121 (8.5) | 43 (4.3) | <0.001 | 13 (3.5) | 25 (5.3) | 5 (3.1) | 0.02 |
| T2 | 508 (20.9) | 259 (18.2) | 249 (24.8) | 97 (26.3) | 127 (26.7) | 25 (15.6) | ||
| T3 | 1,167 (48.0) | 585 (41.0) | 582 (57.9) | 205 (55.6) | 274 (57.6) | 103 (64.4) | ||
| T4 | 509 (20.9) | 395 (27.7) | 114 (11.3) | 45 (12.2) | 43 (9.0) | 26 (16.3) | ||
| T1/T2 | 83 (3.4) | 66 (4.6) | 17 (1.7) | 9 (2.4) | 7 (1.5) | 1 (0.6) | ||
| Lymph node status (N) | ||||||||
| N0 | 1,046 (43.0) | 594 (41.7) | 452 (45.0) | <0.001 | 161 (43.6) | 235 (49.4) | 56 (35.0) | 0.01 |
| N1 | 1,311 (53.9) | 761 (53.4) | 550 (54.7) | 206 (55.8) | 241 (50.6) | 103 (64.4) | ||
| NX | 74 (3.0) | 71 (5.0) | 3 (0.3) | 2 (0.5) | 0 (0) | 1 (0.6) | ||
| Stage | ||||||||
| IIA | 844 (34.7) | 440 (30.9) | 404 (40.2) | <0.001 | 144 (39.0) | 216 (45.4) | 44 (27.5) | <0.001 |
| IIB | 428 (17.6) | 269 (18.9) | 159 (15.8) | 62 (16.8) | 75 (15.8) | 22 (13.8) | ||
| III | 1,159 (47.7) | 717 (50.3) | 442 (44.0) | 163 (44.2) | 185 (38.9) | 94 (58.8) | ||
| Tumor grade | ||||||||
| G1/2 (well/moderate) | 1,137 (46.8) | 652 (45.7) | 485 (48.3) | <0.001 | 170 (46.1) | 233 (49.0) | 82 (51.3) | 0.05 |
| G3/4 (poor/undifferentiated) | 944 (38.8) | 493 (34.6) | 451 (44.9) | 163 (44.2) | 221 (46.4) | 67 (41.9) | ||
| Unknown | 350 (14.4) | 281 (19.7) | 69 (6.9) | 36 (9.8) | 22 (4.6) | 11 (6.9) | ||
| Cause of death | ||||||||
| Alive | 648 (26.7) | 307 (21.5) | 341 (33.9) | <0.001 | 160 (43.4) | 131 (27.5) | 50 (31.3) | <0.001 |
| Esophagus | 1,410 (58.0) | 893 (62.6) | 517 (51.4) | 165 (44.7) | 264 (55.5) | 88 (55.0) | ||
| Other cause of death | 373 (15.3) | 226 (15.8) | 147 (14.6) | 44 (11.9) | 81 (17.0) | 22 (13.8) |
Values are counts and % if not otherwise indicated.
*
Comparison of radiotherapy only versus others;
†
Comparison of surgery only, preoperative, and postoperative radiotherapy;
‡
One-way ANOVA. RT: radiation therapy.