Skip to main content
. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Neurosurg Anesthesiol. 2012 Oct;24(4):368–375. doi: 10.1097/ANA.0b013e31826a03a6

Figure 3. Propofol inhibits the acquisition of neuronal polarity.

Figure 3

A: Cortical neuron cultures were treated with 3 μM propofol for four hours immediately after plating and assayed for neuronal polarity on DIV1. Similarly to isoflurane, propofol significantly reduces the mean percentage of polarized neurons. B: The GABAAR agonist muscimol does not alter mean percentage of polarized neurons in the same exposure paradigm, suggesting that the effects of isoflurane and propofol on axon specification do not occur via activity at GABAARs. n = 666 cells in 61 fields for A and n = 527 cells in 60 fields for B. * = p<0.05