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. Author manuscript; available in PMC: 2013 Oct 16.
Published in final edited form as: Cancer Cell. 2012 Oct 16;22(4):547–560. doi: 10.1016/j.ccr.2012.08.014

Figure 4. Palmitate Metabolism and Its Effect on DLBCL Proliferation and Survival.

Figure 4

(A–B) 13C isotopomer analysis of uniformly labeled palmitate (U13C-Palmitate). (A) Schematics depicting the number of carbons labeled (filled circles) in a defined set of metabolites derived from palmitate. Metabolites marked in red are selectively elevated in OxPhos-DLBCL cell lines (B). (B) 13C enrichment in palmitate-derived metabolites. For each metabolite, cumulative data obtained from all 4 OxPhos-DLBCL cell lines are shown relative to the mean value of that metabolite in all 4 BCR-DLBCL cell lines listed on top.

(C) Effect of palmitate supplementation on the proliferation of DLBCL cell lines. Control denotes serum-free media containing all amino acids except L-glutamine.

(D) Survival of DLBCL subsets cultured in the absence or presence of BrCA for 24 hr.

Error bars, ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; two-tailed Student’s t-test.

See also Figure S3.