Table 1. Pilot Clinical Findings in Melanoma.

					Therapy
Signaturea	TL-ELNs	Sample No.a	Tumor Location	Time (in months)b	None	Surgery	Chemoe	XRT	Other
+	+	112	Pancreas	180c,d			+		Ipi
+	+	115	Lung	114c,d		+
+	+	116	Lung	72c,d		+		+
+	+	113	Lung	72c		+	+
+	+	118	Pelvic soft tissue	65c	+
−	−	5	Liver	36			+
−	−	1	Brain	35		+		+
−	−	3	Brain	30		+		+	IFN
−	−	6	Skinf	13		+
−	−	7	Node	8	+

^aSee Figure 2c.

^bTime (in months) since primary melanoma to death or present date of evaluation.

^cp = 0.008 compared to signature − group (exact Wilcoxon rank sum test).

^dAlive as of May 1, 2012.

^eChemotherapy drugs included: carbo-taxol (1 patient), temozolomide (2 patients), liposomal cytarabine and sagopilone (1 patient each).

^fSubcutaneous metastasis.

Abbreviations: Ipi, ipilimumab; IFN, interferon-alfa; XRT, external beam radiation therapy.