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. 2012 Aug 6;109(42):E2895–E2903. doi: 10.1073/pnas.1121081109

Fig. 7.

Fig. 7.

Behavioral abnormalities and hippocampal remodeling in hAPP mice 35 d after the end of LEV treatment. Four- to six-month-old NTG and hAPPJ20 mice were treated s.c. with saline or LEV (75 mg⋅kg−1⋅d−1) for 28 d (n = 7–9 mice per genotype and treatment). (A and B) Thirty-five days after the end of the treatment, mice were retested in the open field (A) and the elevated plus maze (B). Two-way ANOVA revealed a significant effect of genotype (A, P = 0.0009; B, P = 0.0054) but not treatment (A, P = 0.88; B, P = 0.58) and no interaction between genotype and treatment (A, P = 0.48; B, P = 0.56). (C and D) Coronal brain sections from these mice were immunostained for calbindin and Fos. Calbindin levels in the molecular layer of the dentate gyrus were quantified by densitometry (C), and the average number of Fos-immunoreactive cells in the granular layer of the dentate gyrus per section was counted (D). Two-way ANOVA revealed a significant effect of genotype (C and D, P < 0.0001) but not treatment (C, P = 0.22; D, P = 0.73) and no interaction between genotype and treatment (C, P = 0.7; D, P = 0.45). *P < 0.05, **P < 0.005, ***P < 0.0005 vs. saline-treated NTG (Bonferroni test). Values are means ± SEM.