Table 1.

Acute effects of different antiepileptic drugs in hAPPJ20 mice

FDA-approved antiepileptic drugs	Acute injection dose (mg/kg)	Fraction of mice with >50% spike reduction	Change in spikes relative to baseline (%)*	Statistical significance†	Effect
Ethosuximide	400	1/6	−0.8 (± 18.9)	P = 0.96	None
Gabapentin	100	0/4	−10.3 (± 12.1)	P = 0.45	None
Levetiracetam	200	7/7	−70.6 (± 4.9)	P < 0.0001	Suppression
Phenytoin	100	0/3	+183.2 (± 48.7)	P = 0.043	Exacerbation
Pregabalin	200	0/3	+87.7 (± 14.6)	P = 0.026	Exacerbation
Valproic acid	300	0/4	+20.3 (± 15.4)	P = 0.28	None
Vigabatrin	300	0/4	+0.8 (± 15.6)	P = 0.96	None

*Over a period of 6 h postinjection.

^†One-sample t test compared to baseline.