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The NPC transport highway where Kapβ1 traffic can proceed via at least two “lanes” at physiological concentrations. Slow transport is anticipated for strongly bound Kapβ1 molecules (dark green) that saturate semicollapsed FG domains around the pore walls. Fast transport occurs nearer the pore center, where Kapβ1 binds weakly to unoccupied FG domain protrusions (light green). Small passive molecules (red watermarked) may diffuse freely through the pore center.
