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. 2012 Sep 17;109(40):16143–16148. doi: 10.1073/pnas.1208253109

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Fig. 1. — Cosmc disruption (EHC Cosmc^−/y) results in hemorrhage and loss of T-synthase activity. (A) E15.5 embryos (EHC Cosmc^−/y) reveal hemorrhaging, denoted by arrows. (Scale bars, 1 mm.) (B) RT-PCR analysis of Cosmc transcription level in different platelet genotypes. (C and D) T-synthase activity in platelets isolated from EHC Cosmc^+/y, EHC Cosmc^+/−, and EHC Cosmc^−/y. α-Mannosidase II activity shown as a control. Error bars indicate ±1 SEM of two independent experiments. (E) Flow cytometry analysis of EHC Cosmc^+/y and EHC Cosmc^−/y platelets, stained with anti-CD41 and anti-Tn antigen antibodies. (F) Western blot of platelet lysates from wild-type mice (Cosmc^+/y), EHC Cosmc^+/− mice, and EHC Cosmc^−/y mice, using biotin labeled anti-Tn antigen antibody. GAPDH was used as a loading control.