Fig. 2.
EHC Cosmc-deficient animals have prolonged bleeding times and macrothrombocytopenia. (A) Tail-bleeding time (s) in three different mouse genotypes (n = 6–7). Cautery of mice with continued bleeding was performed at 600 s (red arrow). (B) Peripheral platelet counts in EHC Cosmc+/y, EHC Cosmc+/−, and EHC Cosmc−/y mice. *P = 0.00023, **P = 0.0000002 (equal variance). Error bars indicate ± 1 SD (n = 6). (C) Panels C-1 and C-3 (EHC Cosmc+/y), and C-2 and C-4 (EHC Cosmc−/y) show images of platelets (arrows) from blood smears stained by Wright-Giemsa (C-1 and C-2), or viewed by transmission electron microscopy (C-3 and C-4).