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. 2012 Sep 17;109(40):16143–16148. doi: 10.1073/pnas.1208253109

Fig. 3.

Fig. 3.

Cosmc-deficient platelets have impaired platelet GPIbα expression and function. (A) Platelet surface GPIbα expression as measured by flow cytometry (n = 4, *P = 0.0122, equal variance). (B) Western blot of GPIbα in platelet lysates in reducing and nonreducing conditions. (C) Flow cytometry of botrocetin-treated EHC Cosmc+/y and EHC Cosmc−/y platelets in the presence of VWF and incubated with FITC-labeled anti-VWF antibody. (D) Botrocetin-activated EHC Cosmc+/y and EHC Cosmc−/y platelets were allowed to adhere to BSA or VWF. Adherent platelets were stained with fluorescein-labeled phalloidin.