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. 2012 Sep 17;109(40):16318–16323. doi: 10.1073/pnas.1206834109

Fig. 4.

Fig. 4.

Fear extinction modifies glutamatergic synaptic transmission in IL L5 pyramidal neurons of adult mice. (A) Frequency and amplitude of sEPSCs in IL L5 pyramidal neurons from control (n = 14 neurons, 7 mice), fear-conditioned (n = 17 neurons, 8 mice), and fear-extinguished adult mice (n = 15 neurons, 8 mice). The amplitude of sEPSCs was significantly increased in fear-extinguished mice. (B) EPSC amplitude in IL L5 pyramidal neurons from control (n = 8 neurons, 5 mice), fear-conditioned (n = 10 neurons, 5 mice), and fear-extinguished adult mice (n = 9 neurons, 5 mice). EPSC amplitude was significantly increased in fear-extinguished mice. (C) AMPA/NMDA ratio in IL L5 pyramidal neurons from control (n = 9 neurons, 5 mice), fear-conditioned (n = 12 neurons, 5 mice), and fear-extinguished adult mice (n = 13 neurons, 5 mice). AMPA/NMDA ratio was significantly increased in fear-extinguished mice. (D) Histograms showing the average density of c-Fos–labeled nuclei in the IL across behavioral treatment group reveal increased density of c-Fos expression in the IL of adult fear-extinguished mice compared with fear-conditioned mice (Adult Fear Cond 1,650 ± 29.08; Adult Ext 2,257 ± 26.13), Student t test, *P < 0.01. See also Fig. S2–S10.