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Effector function of T-CD4 T cells is not affected by the strength of TCR signaling. Splenic CD4 T cells from indicated mice were enriched and cultured under the Th1 differentiating condition followed by intracellular staining of IFN-γ and IL-4. Shown is the representative staining profiles of the indicated chimeras using RASA1−/− (Upper) or Itk−/− (Lower) BM. RASA1−/−, six pairs of mice; Itk−/−, three pairs of mice.
