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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2012 May 27;7(3):533–538. doi: 10.1007/s11481-012-9375-y

Fig. 2.

Fig. 2

Effects of MPTP treatment in the striatum of WT and CB1/CB2 KO mice. a) Mice were injected with MPTP (10 mg/kg) and sacrificed 1, 2, 4, or 8 h later. Zero time mice were treated with saline and sacrificed 1 h later. MPP+ concentrations were measured in the striatum using HPLC-MS. Data points represent mean MPP+ (ng/mg protein) ± 1 SEM, n=5. Filled symbols indicate values in MPTP treated mice significantly different from zero time controls of the same genotype (p≤0.05). * Indicates values in WT mice significantly different from CB1/CB2 KO mice at the corresponding time point (p≤0.05). b & c) Mice were treated with saline or MPTP (10 mg/kg) daily for 5 days and decapitated 3 days after the final injection. TH and ser40TH protein were normalized to β-III tubulin. TH protein (b) and ser40TH (c) data are expressed as mean normalized RDU + 1 SEM, n=6–10. * Indicates values in MPTP treated mice significantly different from saline controls of the same genotype (p≤0.05) d e & f) Mice were treated with either saline or MPTP (20 mg/kg) daily for 5 days and decapitated 3 days after the final injection. Concentrations of DA (d), DOPAC (e), and DOPAC/DA (f) were measured in the striatum. Columns represent means (ng/mg protein) as determined by HPLC-ED + 1 SEM, n=9–11. * Indicates values in MPTP treated mice significantly different from saline controls of the same genotype (p≤0.05).