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. Author manuscript; available in PMC: 2012 Oct 24.
Published in final edited form as: J Med Chem. 1989 Aug;32(8):1873–1879. doi: 10.1021/jm00128a031

Table II.

Synthesis and Characterization of 1,3-Dialkyl-5-(acylamino)-6-aminouracils

graphic file with name nihms410759u4.jpg
compd R R1 X % yield mp, °C formula anal.
10a Me cyclopentyl S 71 253 C12H18N4O2S C, H, N
10b Pr cyclopentyl S 92 103 C16H26N4O2S·H2O C, H, N
10c Me 2-thienyl O 76 >300 C11H12N4O3S C, H, N
10d Me 3-thienyl O 78 >300 C11H12N4O3S C, H, N
10e Pr 2-thienyl O 88 143 C15H20N4O3S C, H, N
10f Pr 3-thienyl O 88 144 C15H20N4O3S H, N; Ca
10g Me 2-thienyl S 83 >300 C11H12N4O2S2 C, H, N
10h Pr 2-thienyl S 80 150 C15H20N4O2S2 C, H, N
a

C: calcd, 53.56; found, 52.95.