Table 2.
Effects of SRFE on serum ethanol and acetaldehyde concentrations in acutely inebriated rats.
| Groups | Doses | Ethanol | Ethanol | Acetaldehyde | |||||
|---|---|---|---|---|---|---|---|---|---|
| (g/kg) | (g/kg) | T max (h) | C max (g/L) | AUC (g·h/L) | T max (h) | C max (mg/L) | AUC (mg·h/L) | ||
| Model | — | 4.50 | 2.94 ± 0.78 | 2.40 ± 0.31 | 8.12 ± 1.14 | 3.11 ± 0.73 | 73 ± 6 | 316 ± 38 | |
| SRFE | 0.04 | 4.50 | 2.06 ± 0.76 | 3.55 ± 0.39∗ | 12.89 ± 1.57∗ | 2.61 ± 0.67 | 68 ± 6 | 332 ± 36 | |
| 0.08 | 4.50 | 2.94 ± 0.78 | 1.52 ± 0.15∗ | 5.38 ± 0.49∗ | 1.28 ± 0.25∗ | 53 ± 4∗ | 226 ± 17 | ||
| 0.16 | 4.50 | 2.05 ± 0.53 | 1.35 ± 0.18∗∗ | 4.81 ± 0.91∗ | 1.50 ± 0.58 | 43 ± 5∗∗ | 159 ± 16∗∗ | ||
| HWJZ | 0.25 | 4.50 | 0.83 ± 0.17∗ | 2.37 ± 0.35 | 8.08 ± 1.14 | 1.11 ± 0.23∗ | 74 ± 10 | 265 ± 33 | |
SRFE: Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae extract; HWJZ: Hai-Wang-Jin-Zun tablet; T max: time to peak concentration; C max: peak concentration; AUC: area under the curve. Means ± S.E.M., n = 9. *P < 0.05, **P < 0.01 versus model.