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. 2012 Sep 26;279(1747):4677–4685. doi: 10.1098/rspb.2012.1792

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This journal is © 2012 The Royal Society

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Transmission success in mixed-genotype infections. In mixed infections with a common competitor (DK), virulent (CW_vir) parasites have a transmission (fitness) advantage over avirulent (CW_avir) parasites, which is enhanced by treatment with pyrimethamine. Transmission success is presented as the mean ± s.e. of the proportion of CW alleles, relative to DK alleles, within infected mosquitoes. Treatment groups with sample sizes (number of feeds resulting in infected mosquitoes for avirulent and virulent CW genotypes) were: Placebo: no drugs (N_avir = 5, N_vir = 3); PYR: pyrimethamine at 1 or 3 mg kg⁻¹ (N_avir = 8, N_vir = 7); ART: artemisinin at 50 or 100 mg kg⁻¹ (N_avir = 8, N_vir = 8) and feeds were carried out on days 7, 11, 15 and 19 post infection.