Fig. 1.

Histologic and immunologic features of molecular apocrine breast cancer (MABC). It shows abundant granular eosinophilic cytoplasm, cytoplasmic vacuolization and vesicular nuclei with prominent nucleoli on histology (A). It is negative for estrogen receptor (B), but is also frequently positive for human epidermal growth factor receptor 2 (C), androgen receptor (D) and gamma-glutamyltrasferase 1 (E). The expression of basal markers such as epidermal growth factor receptor (F) and cytokeratin 5/6 (G) is also occasionally seen in cases of MABC.