Table 4. Toxicity scales for radiation pneumonitis.
Criteria | 1 | 2 | 3 | 4 |
CTCAE v.2.0 | Radiographic changes but asymptomatic or symptoms not requiring steroids | Radiographic changes and requiring steroids | Requiring oxygen | Requiring assisted ventilation |
CTCAE v.3.0 | Asymptomatic; radiographic findings only | Symptomatic; not interfering with ADL | Symptomatic; interfering with ADL; O2 indicated | Life-threatening; ventilatory support indicated |
RTOG/EORTC (LENT-SOMA) | Asymptomatic or mild symptoms (dry cough), with radiographic findings | Moderately symptomatic (severe cough, fever) | Severely symptomatic | Severe respiratory insufficiency; continuous oxygen/assisted ventilation |
SWOG | Asymptomatic or symptoms not requiring steroids, with radiographic findings | Initiation or increase in steroids required | O2 required | Assisted ventilation necessary |
ADL, activities of daily living; CTCAE, Common Terminology Criteria for Adverse Events; EORTC, European Organisation for Research and Treatment of Cancer; LENT-SOMA, Late effects of normal tissue: subjective, objective, management and analysis; RTOG, Radiation Therapy Oncology Group; SWOG, Southwest Oncology Group.