Figure 2.
For eight clones (legend, colours reflect virulence measured as maximum anaemia), across days post infection (x-axis), (a) effective propagation Pe (standard errors shown as vertical lines); (b) changes in RBC density (×10−2 μl–1) not due to parasites (range across mice in each clone on each day indicated by vertical bars); values less than 0 (horizontal bar) indicate that destruction by immune effectors or the spleen exceeds replenishment; and (c) effective reproduction number, Re; values less than 1 (horizontal line) indicate that the parasite population is shrinking; and (d) proportion of reticulocytes at every time point obtained from combined RBC and parasite dynamics (see text); either assuming that normocytes are mostly infected (solid line) or assuming that reticulocytes are mostly infected (dotted line).